Hepatic Sinusoid

A specialized, discontinuous capillary channel within the liver lobule lined by fenestrated liver sinusoidal endothelial cells (LSECs) and populated by Kupffer cells and other nonparenchymal cells; sinusoids lack a continuous basement membrane and permit plasma and blood‑borne substrates to access hepatocyte surfaces and resident macrophages for metabolic exchange, clearance and immune surveillanc