 ##  [Tight Junction Disruption](/tight-junction-disruption) 

  ##  [Tight Junction Disruption](https://natural.quantumdictionary.io/tight-junction-disruption-0) 

  
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**Natural &amp; Formal Sciences Dictionary**

 
Definition

Loss of integrity or organization of tight junction complexes between epithelial or endothelial cells that normally restrict paracellular transport, leading to increased leakiness of the cell layer.