 ##  [Structure–Activity Relationship](/structure-activity-relationship) 

  ##  [Structure–Activity Relationship](https://natural.quantumdictionary.io/structure-activity-relationship-0) 

  
 [![Natural & Formal Sciences Dictionary](/sites/default/files/styles/large/public/2026-01/Natural%20%26%20Formal%20Sciences.png.webp?itok=2kCDRVQv)](/topic-specific-dictionaries/natural-formal-sciences)


**Natural &amp; Formal Sciences Dictionary**

 
Definition

The correlation between chemical structure (substituents, stereochemistry, conformation, electronic distribution) and a molecule's biological or functional activity (binding affinity, potency, efficacy), commonly used to guide medicinal chemistry optimization.