##  [Ubiquitin-Proteasome System](/index.php/ubiquitin-proteasome-system) 

  ##  [Ubiquitin-Proteasome System](https://health.quantumdictionary.io/ubiquitin-proteasome-system-0) 

  

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**Health & Life Sciences Dictionary**

 







 

 

 

 



 

 

 

 

Definition

Intracellular pathway in which proteins are covalently tagged with one or more ubiquitin molecules through an E1–E2–E3 enzymatic cascade and, when marked by degradation-associated ubiquitin signals, are recognized, unfolded and proteolytically degraded by the 26S proteasome; this system controls selective protein turnover and modulates signaling by removing specific soluble or short-lived proteins