 ##  [Haldane's Rule](/haldanes-rule) 

  ##  [Haldane's Rule](https://natural.quantumdictionary.io/haldanes-rule-0) 

  
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**Natural &amp; Formal Sciences Dictionary**

 
Definition

An empirical pattern in hybridization and speciation stating that when hybrid inviability or sterility affects only one sex of the offspring of a cross between species, it is most often the heterogametic sex (the sex with two different sex chromosomes).