##  [Cellular Senescence](/cellular-senescence) 

  ##  [Cellular Senescence](https://health.quantumdictionary.io/cellular-senescence-0) 

  

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**Health & Life Sciences Dictionary**

 







 

 

 

 



 

 

 

 

Definition

A stable and generally irreversible state of permanent cell‑cycle arrest in which cells remain metabolically active and adopt characteristic changes—altered chromatin, resistance to mitogenic stimuli and a proinflammatory secretory profile (senescence‑associated secretory phenotype, SASP)—that modify the tissue microenvironment.